Abstract: Soda saline-alkali water was added into the water from desalinated prawn pond, to study the juvenile Litopenaeus vannamei adaptability to saline-alkali water. A one-way toxicity test and a live ability test of juvenile shrimp were carried out in saline-alkali soda lakes. Results show medium effect concentration (EC₅₀) of alkalinity for juvenile shrimp in 24 hours to be 2.73mmol/L, medium lethal concentration (LC₅₀) in 24hrs, 48hrs and 96hrs to be 12.40mmol/L, 11.24mmol/L and 10.49mmol/L respectively, and safe concentration (SC) to be 2.77mmol/L. When alkalinity is 5.37～14.66mmol/L, medium lethal pH (LpH₅₀) in 24hrs, 48hrs, 72hrs and 96hrs of juvenile shrimp are 9.26～8.98，9.14～8.86，9.10～8.80 and 9.00～8.80 respectively, and safe pH (SpH) is 8.42～8.14. Juvenile shrimp can survive 4.8～9.2hrs in saline-alkali soda lakes at an alkalinity of 18.68～38.78mmol/L, salt content of 1.57～3.50g/L and pH level of 8.5～9.5. The adaptability of desalinated juvenile shrimp to alkalinity and pH is poorer than that of freshwater fishes and its comprehensive adaptive capacity to saline-alkali soda lakes of northeast China is lower too.