Abstract: The grey desert soil was selected as the objective to study the dynamical changes of soil enzyme,soil chemical and physical properties through comparing the soil changes under different fertilizers in a long-term located experiment.The result shows that the main nutrient contents and soil enzyme activities are increased with the fertilizer added.Soil enzyme,soil chemical and physical properties are evidently different among different fertilizer treatments.Nitrogen and soil organic matter are the key control factors of soil enzyme and the yield of wheat in grey desert soil.Soil organic,soil total nitrogen and available nitrogen have obvious effects on soil proteinase activity,phosphatase activity,urease activity,and invertase activity.There is a significant correlation among soil enzyme,soil chemical and physical properties.