Abstract: National agricultural science and technology parks have developed rapidly since the start of construction in 2001. Many national agricultural science and technology parks have been the innovation base of regional agricultural science and technology demonstration of new crop varieties and technologies and the transformation base of scientific achievement in over 10 years of development. The development of national agricultural science and technology parks have significantly contributed to yield improvement, improvement of agricultural resources use efficiency and increase of farmer inputs. However, different national agricultural science and technology parks have various development modes because of differences in construction backgrounds, basic conditions, development direction, etc., all of which have specific development mode problems. This paper analyzed different development modes of national agricultural science and technology parks and summarized the related problems on the basis of lessons learned from previous achievements based on field investigation, literature review and comprehensive analysis. The Cangzhou National Agricultural Science and Technology Park in Hebei Province is one of the six batch parks approved by the Ministry of Science and Technology of the People’s Republic of China. This park was developed to help implement the “Bohai Granary” project and it mainly focused on grain yield improvement, high agricultural resources use efficiency and industrial development of food in medium and low grain yield regions nearby Bohai Sea. The paper also discussed the development mode of the Cangzhou National Agricultural Science and Technology Park in terms of its overall planning, construction background, planning idea, construction goal, functional localization and industrial development. The development of the Cangzhou National Agricultural Science and Technology Park was based on the mode of organizational development, technological operation and spatial distribution. Also the development of the park was guided by the government in terms of the main body of organizational enterprise development, triple-technology operation, core demonstration and radiation zones, and triple-tier spatial distribution. The mode of organizational development was guided by the local government. The local government mainly organized park committees, passed policies, and undertook planning, construction and operation. The enterprise and farmers took part in the management of the park. The mode of technologic operation was mainly by spreading technologies from the park to farmers using technological stations, basic stations and special science commissioners. The mode of spatial distribution developed three areas, including the core area (mainly located at the “Bohai Granary” experimental area in Nanpi County), demonstration area (mainly distributed in Cangzhou City) and radiation area (mainly including Hebei Province, Shandong Province, Tianjin City and Liaoning Province around the Bohai region). The core area comprised of two parks, three areas, two networks and one route. The functional subarea consisted of science and technology innovation park, industrial agglomeration park, improved variety breeding area, high yield and efficiency area, animal eco-farming area, water resources control network, large agricultural data network, and eco-tourism and cultural route.