Abstract: According to natural resources, environment and economic condition in vulnerable environmental karst region of Southwest China,the character of resources absence and the slow cause of agricultural economy are analyzed.Coordinated development countermeasures of agriculture and environment,and period development theory are put forward such as developing mainstay industry chain firstly,strengthening integrated devotion,building resource base,constructing antipoverty entity,adjusting the relationship between population and nature,enhancing the progress of sciences and technology,pushing the move system of land.