Abstract: The concept of functional orientation of eco-economic regions (as defined in previous studies) is re-examined in this study. The dominant resources of economic development in the Loess Plateau were identified, and their distribution and exposition were systematically discussed. Meanwhile, a regional quotient method was used to analyze the comparative dominances in industries and resources of 18 eco-economic regions of the Loess Plaeteau. Furthermore, the study summarized relatively important ecological function regions and their regional distribution patterns. Finally, the study used systematic analysis and comprehensive induction to explain functional orientation of eco-economic regions in the Loess Plateau.