Abstract: Based on the Artificial Soil Test, acute toxicities of combined two pollutants among chloride cadmium, malathion and acetochlor with 5 different ratios are tested on Eisenia fetida earthworm. The results show that interactions between two pollutants in each group are almost antagonistic. The interaction between 19.46 mg·kg^-1 of cadmium and 175.15 mg·kg^-1 of acetochlor in the ratio of 1︰9 is, however, an additive effect. This indicates that the eco-toxic effect of combined pollutants is related with the chemical characteristic and concentration of the pollutants. In the combined contamination test, the effect of each pollutant on the growth of earthworm is similar to its independent effects. The toxicities of the 3 pollutants respectively rank from serious to light for malathion, acetochlo and cadmium