Abstract: Fusaric acid (FA) is a secondary metabolite produced by fungi in the Fusarium genus. FA not only causes severe damage to plants, but also exhibits toxicity to humans and animals. FA contamination is widespread in vegetables, fruits, cereal crops, and animal feed, and poses a substantial threat to agricultural production and food safety. This review summarizes the current status of FA contamination, its biosynthetic pathways, toxic effects on plants, underlying mechanisms, and strategies to mitigate FA pollution. FA disrupts plant cell function by interfering with the antioxidant system, inducing oxidative stress, and triggering cell death, thereby creating conditions for further infection by Fusarium. Traditional methods for controlling FA contamination face challenges, such as the lack of resistant crop varieties, pathogen resistance, and environmental pollution. Biological control has shown promise as a sustainable alternative. By screening and utilizing FA-tolerant biocontrol agents and studying microbial mechanisms, such as efflux pumps, degradation, or transformation of FA, this review provides important insights for developing novel biocontrol strategies. This study offers new perspectives for reducing FA contamination and ensuring the safety of agricultural products.